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International Congress of Immunology 2016
Abstract Book
human cytomegalovirus, which led to the identification of their
viral ligand, a pentameric complex that was then produced and
tested as an effective vaccine. By reconstructing the genealogy
trees of specific B cell clones, we investigate the role of somatic
mutations in affinity maturation and in generation of antibody
variants with broader or different specificity. Somatic mutations
can also generate autoantibodies, as found in patients with
pemphigus and autoimmune pulmonary alveolar proteinosis.
Recently, while searching for antibodies that broadly react with
malaria variant antigens, we discovered a new mechanism of
antibody diversification, which relies on the interchromosomal
transposition of genomic DNA sequences into rearranging T cell
subsets in regulation of autoimmunity and anti-tumor immunity