EACS2023: 257 Effect of HAAST on fungal dermatosis amongst HIV patients in Benin City, Edo State, South-South, Nigeria E.O. Omatighene , A.N. Onunu , B. Okwara , C.R. Madubuko Delta State University Teaching Hospital, Internal Medicine, Oghara, Nigeria, University of Benin Teaching Hospital, Internal Medicine, Benin, Nigeria General data Abstract category: Antiretroviral therapy – observational studies Abstract body Purpose: To determine the effects of HAART on the prevalence of fungal dermatoses amongst HIV infected patients in University Of Benin Teaching Hospital. The specific goal is to determine the difference in the prevalence of fungal dermatoses in HIV infected patients who are HAART experienced and HAART naïve. Method: A comparative cross-sectional study design was used after obtaining an ethical clearance certificate from the University of Benin Teaching Hospital. A total of 300 patients were recruited for the study after informed consent had been obtained. One hundred and fifty were HAART experienced for six months and above, while one hundred and fifty were HAART naïve (these patients just presented for the first time with positive HIV results). An interviewer-administered questionnaire was used to obtain sociodemographic characteristics and relevant clinical history. Patients were examined for fungal dermatoses and diagnosis recorded. Dermoscopy was utilized where applicable to boost diagnostic accuracy. Laboratory procedures were done for confirmation of diagnosis. These include skin scrapings for all patients and skin biopsy. Random blood sugar was also done to exclude patients with undiagnosed diabetes. All data were collated and analyzed using SPSS version 25. A significant relationship using Pearson’s Chi-square with value<0.05 was considered significant, and also T-test and ANOVA test. Results: Females were more than males in both study groups, 76% and 66.6% in the HAART experienced and HAART naïve group, respectively. The mean ages were 45.02±11.23 years and 42.62±12.22 years for the HAART experienced and HAART naïve group. The prevalence of fungal dermatoses was 14% in the HAART experienced group and 24.6% in the HAART naive group ( =5.47, p=0.02). The odds ratio for fungal dermatoses in the HAART naive was twice that of the HAART experienced. Conclusions: This study has shown that HAART reduces the prevalence of fungal dermatoses in HIV positive patients. General conditions 1. I confirm that I previewed this abstract and that all information is correct. I accept that the content of this abstract cannot be modified or corrected after the submission deadline and I am aware that it will be published exactly as submitted.: Yes 2. I confirm that the submission of the abstract constitutes my consent to publication (e.g. conference website, programmes, other promotions, etc.). : Yes 3. I herewith confirm that the contact details saved in this system are those of the corresponding author, who will be notified about the status of the abstract. The corresponding author is responsible for informing the other authors about the status of the abstract.: Yes 4. I agree that all data provided may be used (saved, stored, processed, transmitted and deleted) in compliance with the privacy policy to provide the services described.: Yes 1 2 2 2 1 2 93
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