EACS2023: 948 Cognitive frailty in people living with HIV and its association with geriatric syndromes J. Milic , S. Calza , L. Lazzarini , M. Cocchi , V. Todisco , M. Albertini , A. Gallerani , M. Menozzi , G. Cuomo , G. Mancini , C. Mussi , C. Mussini , G. Guaraldi Jovana Milic, Modena, Italy, University of Brescia, Brescia, Italy, University of Modena and Reggio Emilia, Modena, Italy General data Abstract category: Ageing and frailty Abstract body Purpose: The objective of this study was to describe cognitive frailty (CF) in people living with HIV (PLWH) > 50 years, determine its risk factors and association with geriatric syndromes, namely falls, polypharmacy (PP), physical status evaluated with short performance physical battery (SPPB). Method: This was an observational study including ART-experienced PLWH attending Modena HIV Metabolic Clinic (MHMC) from 2016. Neurocognitive function was measured with Cogstate battery that comprises six domains: simple speed processing, complex speed processing, attention/working memory, visual learning memory, verbal learning and verbal memory. Each individual CogState raw score was transformed into z-score after correction for age and sex. Neurocognitive impairment was defined by total global deficit score >0.5. Frailty was assessed by 16-Item frailty index. Scores <0.36 were considered fit or >0.37 as frail. CF was defined as contemporary presence of neurocognitive impairment and frailty. Results: 1812 PLWH were included, 1333 (73.6%) were males, mean age was 58 years, Mean body mass index was 25 kg/m2, median time since HIV diagnosis was 25 years. CF was present in 247 (13.6%) and incidence was 4.5 x 100 persons/years (Figure 1). PLWH with CF had higher prevalence of obesity (18%vs.10%; p<0.001) and higher levels of chronic inflammation (Figure 2). Polypharmacy was also higher in this group (31% vs 16%; p<0.001). Use of DTG was higher (40% vs 32%; p=0.03) in PLWH with CF. SPPB (OR=0.46, 0.30, 0.66 p<0.001) and polypharmacy (OR=4.75, 1.24, 18.9 p=0.023) were associated with higher risk of CF. Conclusions: CF was highly prevalent in PLWH >50 years, similarly to what was observed in the general population > 65 years, and it was associated with SPPB score and polypharmacy, but not with falls. Further studies are needed to explore CF in relation to HIV-related variables, inflammation, mortality and traditional geriatric outcomes, such as falls, disability. General conditions 1. I confirm that I previewed this abstract and that all information is correct. I accept that the content of this abstract cannot be modified or corrected after the submission deadline and I am aware that it will be published exactly as submitted.: Yes 2. I confirm that the submission of the abstract constitutes my consent to publication (e.g. conference website, programmes, other promotions, etc.). : Yes 3. I herewith confirm that the contact details saved in this system are those of the corresponding author, who will be notified about the status of the abstract. The corresponding author is responsible for informing the other authors about the status of the abstract.: Yes 4. I agree that all data provided may be used (saved, stored, processed, transmitted and deleted) in compliance with the privacy policy to provide the services described.: Yes 1 2 3 3 3 3 3 3 3 3 3 3 3 1 2 3 75
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