EACS2023: 529 Frailty and quality of life for people with HIV in Cyprus: re-visiting the cascade of care A. Kapetanakis , G. Siakallis , M. Panagi , N. Vrontaras , D. Kyrou , I. Ntourou , C. Kakalou , K. Stavrogianni , I. Katsarolis , C. Karamanidou Center for Research and Technology, Hellas, INAB, Thessaloniki, Greece, University of Nicosia Medical School, Department of Basic and Clinical Sciences, Nicosia, Cyprus, Grigorios HIV Reference Clinic, Larnaca General Hospital, Larnaca, Cyprus, Medical Affairs, Gilead Sciences Hellas and Cyprus, Paleo Faliro, Greece General data Abstract category: Ageing and frailty Abstract body Purpose: Frailty, a well-described geriatric syndrome, occurs earlier and is more frequent in people with HIV (PWH) compared to their HIV-negative peers and is associated with significant morbidity and decreased quality of life (QoL). This study aimed to describe frailty prevalence in Cypriot PWH and investigate its impact on the 4 pillar of the care cascade beyond viral suppression: good health-related QoL. Method: Demographic and clinical data were collected cross-sectionally from a sample of 150 PWH in the only HIV clinic in Cyprus (~1200 outpatients actively in follow-up) between November 2021 and June 2022. Frailty was assessed using Fried's frailty phenotype, classifying patients as robust, pre-frail, or frail. QoL was assessed using EQ-5D-5L self-reported questionnaire, with good QoL being considered the report of no and/or slight problems in all dimensions. Results: Median age was 41 years (IQR=15) and 96% were male. All participants were on ART and 93.9% had a viral load <50copies/mL. Approximately half of virally suppressed participants (48.1%) reported good QoL. Weak grip strength was the most prevalent frailty criterion (57%), followed by self-reported exhaustion (24.8%), unintentional weight loss (16.8%), low physical activity (10.1%), and slow walking speed (0.7%). Based on the above, 28.9% of participants were robust, 63.8% prefrail, and 7.4% frail. For virally suppressed participants, frailty phenotype had a significant impact on health-related QoL (p=0.012) ( Figure 1). Anxiety/depression was the most affected QoL dimension, with only 56% having no or slight problems ( Figure 2). Conclusions: Although most PWH on ART in Cyprus are virologically suppressed, only half of them report a good QoL. Frailty greatly impacts QoL, and a worrisome observation is that only less than one-third of participants are robust per Fried’s criteria. Therefore, dealing with frailty is paramount in reaching the 4 90 target. Anxiety/depression is the QoL dimension that needs the greatest clinical attention. General conditions 1. I confirm that I previewed this abstract and that all information is correct. I accept that the content of this abstract cannot be modified or corrected after the submission deadline and I am aware that it will be published exactly as submitted.: Yes 2. I confirm that the submission of the abstract constitutes my consent to publication (e.g. conference website, programmes, other promotions, etc.). : Yes 3. I herewith confirm that the contact details saved in this system are those of the corresponding author, who will be notified about the status of the abstract. The corresponding author is responsible for informing the other authors about the status of the abstract.: Yes 4. I agree that all data provided may be used (saved, stored, processed, transmitted and deleted) in compliance with the privacy policy to provide the services described.: Yes 1 2,3 3 1 1 1 1 1 4 1 1 2 3 4 th th 69
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