EACS2023: 271 Neurocognitive impairment, and anxiety symptoms may influence the development of prefrailty/frailty in Japanese people living with HIV aged over 40 years H. Nakamura , N. Ikemiyagi , W. Arakaki , K. Yamamoto University of the Ryukyus Graduate School of Medicine, First Department of Internal Medicine, Division of Infectious, Respiratory, and Digestive Medicine, Nishihara, Japan General data Abstract category: Ageing and frailty Abstract body Purpose: Despite a rapid increase in the proportion of senior people living with HIV (PLWH) in Japan, few studies have addressed frailty in this population. The aim of this study was to assess the prevalence of frailty and factors that can negatively interplay. Method: This was a cross-sectional analysis of male Japanese PLWH (aged ≥40 years at enrollment) on ART for at least 12 months, attending a tertiary hospital in Okinawa, Japan. Sociodemographic data were extracted from medical records, while frailty was assessed by the Fried frailty assessment. The following information was collected to evaluate the frailty profile: Short Performance Physical Battery (SPPB), Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and the Japanese version of the Montreal Cognitive Assessment (MOCA-J). Results: Among 126 participants (mean age, SD 54.6 ± 8.61), 12 (11.9%) and 77 (61.9%) were frail or prefrail, respectively. Weight loss (38%) and exhaustion (27%) were the main frailty markers. In univariate models, BMI, current smoking, two or more comorbidities, polypharmacy, current CD4 T-cell count, SPPB ≤9, GAD-7 ≥10, PHQ-9 ≥10, and MOCA-J ≤25 were significantly associated with the frail and prefrail phenotype. A multivariate analysis showed that GAD-7 ≥10 (OR 2.47, 95% CI 1.53 – 5.91), and MOCA-J ≤25 (OR 2.81, 95% CI 1.64 – 5.87) significantly differed between frail and prefrail groups versus the robust group. Conclusions: Anxiety and cognitive impairment might be implicated in the development of frailty in this population. Although further investigation is needed to identify the more precise clinical feature of frailty in senior Japanese PLWH, interventions in mental health and cognitive function might contribute to reverse frailty status. General conditions 1. I confirm that I previewed this abstract and that all information is correct. I accept that the content of this abstract cannot be modified or corrected after the submission deadline and I am aware that it will be published exactly as submitted.: Yes 2. I confirm that the submission of the abstract constitutes my consent to publication (e.g. conference website, programmes, other promotions, etc.). : Yes 3. I herewith confirm that the contact details saved in this system are those of the corresponding author, who will be notified about the status of the abstract. The corresponding author is responsible for informing the other authors about the status of the abstract.: Yes 4. I agree that all data provided may be used (saved, stored, processed, transmitted and deleted) in compliance with the privacy policy to provide the services described.: Yes 1 1 1 1 1 66 19TH EUROPEAN AIDS CONFERENCE | WARSAW 2023
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