EACS2023: 108 Predictors of Quality of Life among Older People Living with HIV in Kampala, Uganda E. Senkoro , P. Mbabazi , G. Banturaki , S. Naikoba , B. Castelnuovo , HASA COHORT Ifakara Health Institute, Chronic Disease Clinic of Ifakara, Morogoro, Tanzania, United Republic of, Infectious Disease Institute, Mark Wainberg Fellowship - Research Department, Kampala, Uganda, Infectious Disease Institute, Research Department, Kampala, Uganda General data Abstract category: Ageing and frailty Abstract body Purpose: Older people living with HIV (OPWH) often have lower quality of life (QoL) compared to those without HIV, necessitating efforts to achieving the proposed Joint United Nations Programme on HIV/AIDS (UNAIDS) goal of 90% PLWH having a good QoL. This study examined QoL and its predictors among PWH over 60 years in Uganda. Method: A cross-sectional analysis of OPWH enrolled in a prospective cohort from December 2020 – 2021 was done. QoL was assessed using the World Health Organisation QoL OLD instrument (WHOQOL-OLD, a score of 120 indicates good QoL), which comprises 6 domains where each domain top score is 20; sensory abilities(SAB), death and dying(DAD), past, present and future activities(PPF), autonomy(AUT), social participation(SOP), intimacy(INT). Linear regression model was used to determine factors (e.g, social demographics, HIV/non-HIV clinical factors, geriatric syndromes) associated with QoL. Results: 500 participants were enrolled, 51.2% were men, median age was 64 years (IQR: 62-68) and 92.2% had viral load <50 copies/mL. WHOQOL-OLD mean score(SD) was 90.1(8.3) showing an overall good QoL. For each domain, mean scores (SD) were: SAB 16.9(2.9); DAD 14.9(3.0); PPF 15.1(1.9); AUT 14.5(2.1); SOP 14.4(2.3); INT 14.3(2.2). Physical function, frailty, falls, urinary incontinence, bone density and activities of daily living were significantly associated with at least three domains (SAB, AUT, and SAP) and the overall score. Predictors of good QoL were (Coefficient [95% Confidence Interval]): being male (2.61[1.21 to 4.00]), having an income of ≥$1 and having ≥2 NCDs (0.45[0.11 to 0.80]). Predictors of poor QoL included: depression (-2.77[-5.01 to -0.52]), pre-frailty (-1.87[-3.31 to -0.43]), frailty (-7.28[-10.18 to - 4.38], malnutrition (-3.99[-7.74 to -0.23]), and low physical function (-6.42[-9.40 to -3.45]) for OPWH. Conclusions: Standardising the assessment of frailty, depression, nutrition, and physical function in clinical practice in sub-Saharan Africa could improve the QoL for OPWH. These findings could inform future interventions for OPWH. General conditions 1. I confirm that I previewed this abstract and that all information is correct. I accept that the content of this abstract cannot be modified or corrected after the submission deadline and I am aware that it will be published exactly as submitted.: Yes 2. I confirm that the submission of the abstract constitutes my consent to publication (e.g. conference website, programmes, other promotions, etc.). : Yes 3. I herewith confirm that the contact details saved in this system are those of the corresponding author, who will be notified about the status of the abstract. The corresponding author is responsible for informing the other authors about the status of the abstract.: Yes 4. I agree that all data provided may be used (saved, stored, processed, transmitted and deleted) in compliance with the privacy policy to provide the services described.: Yes 1,2 3 3 3 3 1 2 3 63
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