EACS2023: 177 Antiretroviral treatment failure for adolescents living with HIV in East African Community: a review of literature H. Tarimo University College of London, Institute of Global Health, London, United Kingdom General data Abstract category: Adolescents Abstract body Purpose: The World Health Organization's (WHO) universal HIV 'treat all' program has significantly increased antiretroviral therapy (ART) coverage worldwide (WHO, 2016). However, Adolescents Living with HIV (ALHIV) aged 10 to 19 years, experience increasing AIDS-related mortality due to higher rates of virological treatment failure (Pantelic et al., 2020). In the East Africa Community (EAC) region, virological treatment failure prevalence ranges from 8 to 57 percent among patients on first-line ART (Lailulo et al., 2020). This study aims to review the virological treatment failure among ALHIV in the EAC regions. Method: A literature review was conducted using the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Fourteen articles published from 2010 to 2022 were analyzed to summarize the factors contributing to treatment failure and interventions addressing this issue. Results: The review identified 21 factors contributing to treatment failure among ALHIV in the EAC region. These factors were categorized into four themes: patient barriers, drug barriers, caretaker barriers, and health system barriers. Key barriers included poor adherence, stigma, food insecurity, malnutrition (patient barriers), and drug resistance (drug barriers) (Lailulo et al., 2020). Potential interventions included community-based interventions, adolescent-friendly clinic services, peer health worker support, and the short message reminder system. However, the short message reminder system did not significantly reduce virological treatment failure (Lailulo et al., 2020). Conclusions: To address the prevalence of virological treatment failure among ALHIV in the EAC region, it is vital to integrate community and facility-based interventions (Lailulo et al., 2020). Strengthening coordination between governments and global health actors is crucial. By addressing patient, drug, caretaker, and health system barriers, the effectiveness of ART can be enhanced. Implementation of strategies such as community-based interventions, adolescent-friendly clinic services, peer health worker support, and exploring innovative approaches beyond message reminders can contribute to improved treatment outcomes. General conditions 1. I confirm that I previewed this abstract and that all information is correct. I accept that the content of this abstract cannot be modified or corrected after the submission deadline and I am aware that it will be published exactly as submitted.: Yes 2. I confirm that the submission of the abstract constitutes my consent to publication (e.g. conference website, programmes, other promotions, etc.). : Yes 3. I herewith confirm that the contact details saved in this system are those of the corresponding author, who will be notified about the status of the abstract. The corresponding author is responsible for informing the other authors about the status of the abstract.: Yes 4. I agree that all data provided may be used (saved, stored, processed, transmitted and deleted) in compliance with the privacy policy to provide the services described.: Yes 1 1 61
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