EACS2023: 731 Vaccination against COVID-19 among healthcare workers as a cocoon strategy for HIV-positive patients A. Skrzat-Klapaczyńska , J. Kowalska , F. Fijołek , M. Paciorek , C. Bieńkowski , D. Krogulec , A. Horban Hospital for Infectious Diseases, Medical University of Warsaw, Poland, Adults’ Infectious Diseases, Warsaw, Poland, Hospital for Infectious Diseases, Poland, Adults’ Infectious Diseases, Warsaw, Poland General data Abstract category: Access and delivery of care Abstract body Purpose: Healthcare professionals working in infectious diseases units are often engaged in the care of patients infected with HIV. A cocoon vaccination strategy may prevent those who are immunocompromised from a severe course of COVID-19. Method: The study was conducted between January 2021 and June 2022. The study participants were HCWs from the Hospital for Infectious Diseases in Warsaw, where an average 100 PLWH are hospitalized per month, and they were vaccinated against COVID-19 with the BNT162b2 mRNA vaccine (Pfizer-BioNTech) – first available type of vaccine in Poland. Sera were collected according to the scheme of the study. Results: From 450 HCWs working in the Hospital for Infectious Diseases in Warsaw 412 (91,5%) were vaccinated against COVID-19. In total 170 (41,3%) vaccinated HCWs were included in the final analysis. Their median age was 51 years [interquartile range (IQR): 41–60 years]. Their median body mass index (BMI) was 25.10 [IQR: 22.68–29.03]. Most of the cohort consisted of women (n=137, 80.59%) and most were working directly with patients (n=137, 73.21%) (Table 1). It was found that as early as 14 days after the second dose of the vaccine, 100% of the study participants achieved a positive result for SARS CoV-2 S-RBD antibodies (Figure 1). 168 subjects had COVID-19 diagnosis before entering study, after the vaccination 65 HCWs was diagnosed with COVID-19 (Table 2). Healthcare workers COVID-19 after the first dose of BNT162b2 mRNA vaccine n=1 COVID-19 after the second dose of BNT162b2 mRNA vaccine n=15 COVID-19 after the third dose of BNT162b2 mRNA vaccine n=49 Nurse (number, %) 1 (100) 8 (53) 22 (45) Doctor (number, %) - 2 (14) 12 (24.5) Laboratory diagnostician (number, %) - - 3 (6) Administrative employee (number, %) - 4 (26) 11 (22.5) Medical assistant (number, %) - 1 (7) - Pharmacist (number, %) - - 1 (2) Conclusions: The results of our study indicate a favorable humoral response to vaccination among HCWs working in an infectious disease center with both PLWH and COVID-19 patients. Due to the fact that PLWH with severe immunodeficiency may have an incomplete immune response to COVID vaccination and may be at risk of a severe course of the disease, the cocoon strategy of vaccinating medical personnel may be beneficial for these patients. General conditions 1. I confirm that I previewed this abstract and that all information is correct. I accept that the content of this abstract cannot be modified or corrected after the submission deadline and I am aware that it will be published exactly as submitted.: Yes 2. I confirm that the submission of the abstract constitutes my consent to publication (e.g. conference website, programmes, other promotions, etc.). : Yes 3. I herewith confirm that the contact details saved in this system are those of the corresponding author, who will be notified about the status of the abstract. The corresponding author is responsible for informing the other authors about the status of the abstract.: Yes 4. I agree that all data provided may be used (saved, stored, processed, transmitted and deleted) in compliance with the privacy policy to provide the services described.: Yes 1 1 2 1 1 1 1 1 2 42 19TH EUROPEAN AIDS CONFERENCE | WARSAW 2023
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