EACS2023: 672 What is the profile of patients on the same oral ART for over 10 years: results from the French national survey CONCERTO R. Palich , F. Goehringer , J.-L. Meynard , D. Dei , E. Estrabaud , S. Parlier , L. Roudiere Sorbonne University, Paris, France, AP-HP, Pitie-Salpetriere Hospital, Department of Infectious and Tropical Diseases, Paris, France, Regional University Hospital of Nancy, Department of Infectious and Tropical Diseases, Nancy, France, AP-HP, Saint-Antoine Hospital, Department of Infectious and Tropical Diseases, Paris, France, Gilead Sciences, Paris, France, AP-HP, Saint-Louis Hospital, Center for Genital Pathology and Sexually Transmitted Infections, Paris, France General data Abstract category: Access and delivery of care Abstract body Purpose: Antiretroviral therapy (ART) has undergone considerable development since the introduction of triple therapy nearly 30 years ago. We conducted the CONCERTO survey to investigate the proportion of people living with HIV (PLWH) who have had no change in their ART for over 10 years, as well as the characteristics associated with these PLWH and their doctors. Method: From 06/2022 to 06/2023, we enrolled 62 French HIV physicians in the survey. They completed a 19-item questionnaire and offered 10 consecutive PLWH a 35-item questionnaire during their routine medical visit. To be included, patients had to have been on the same oral ART for over two years. We compared the characteristics of PLWH and doctors according to the duration of the last ART change. Results: Among the 539 PLWH who completed the survey, 32% had been on the same oral ART for over 10 years (median: 6 years (IQR 3-14)). Their characteristics are presented in Table 1. Factors significantly associated with longer duration on current ART included higher age, longer time since HIV diagnosis, being female or being homeless, and taking co-medications. PLWH who had a doctor practicing outside the Paris region, and managing fewer patients with HIV were also less likely to have changed the patients’ ART in the last 10 years. Finally, PLWH who had no change in ART for over 10 years were significantly less likely to be taking only one pill a day ( Table 2) . Table 1 I Characteristics of PLWH respondents and their doctor’s All respondents (N=539) ≤10 years on current ART (N=366) >10 years on current ART (N=173) p-value Gender, n (%) Male Female 356 (67) 175 (33) 252 (70) 108 (30) 104 (61) 67 (39) 0.035 Place of birth, n (%) France Sub-Saharan Africa Other 326 (61) 141 (26) 72 (13) 226 (62) 91 (25) 49 (13) 100 (58) 50 (29) 23 (13) 0.6 Age, years, median (IQR) 51 (39-58) 47 (35-57) 55 (46-61) <0.001 Time since HIV diagnosis, median (IQR), years 15 (7-24) 9 (6-20) 21 (17-28) <0.001 At least one co-medication, n (%) 250 (48) 148 (41) 102 (62) <0.001 Doctor’s location In the Paris region Outside the Paris region 240 (45) 299 (55) 141 (38) 225 (62) 99 (58) 74 (43) <0.001 Doctor’s monthly patient volume, n (%) <50 50 - 99 >100 167 (31) 200 (37) 172 (32) 126 (34) 131 (36) 109 (30) 41 (24) 69 (40) 63 (36) 0.039 Doctor’s age, median (IQR), years 50 (40-56) 48 (40-55) 51 (38-57) 0.5 Doctor’s specialty, n (%) Infectiologist Other 271 (76) 130 (24) 271 (74) 95 (26) 138 (80) 35 (20) 0.1 Doctor’s gender , n (%) Female Male 283 (53) 256 (48) 196 (54) 170 (46) 87 (50) 86 (50) 0.5 Table 2 I Impact of longer time on same ART on PLWH’s HIV treatment All respondents (N=539) ≤10 years on current ART (N=366) >10 years on current ART (N=173) p-value Current HIV treatment Number of tablet(s) /capsule(s) per dose, n (%) 1 2 >2 Packaging, n (%) Bottle Blister pack Injection Other 424 (81) 49 (9) 54 (10) 389 (72) 126 (23) 16 (3) 8 (2) 311 (87) 25 (7) 22 (6) 258 (70) 90 (25) 12 (3) 6 (2) 113 (67) 24 (14) 32 (19) 131 (76) 36 (21) 4 (2) 2 (1) <0.001 0.6 Conclusions: Our study reports that almost one third of PLWH have been treated with the same ART for over 10 years, and suggests that both patient and doctor characteristics are associated with no change in ART treatment. These PLWH may benefit from more recent ARTs which have a better safety profile, are better tolerated, and easier to adhere to. General conditions 1. I confirm that I previewed this abstract and that all information is correct. I accept that the content of this abstract cannot be modified or corrected after the submission deadline and I am aware that it will be published exactly as submitted.: Yes 2. I confirm that the submission of the abstract constitutes my consent to publication (e.g. conference website, programmes, other promotions, etc.). : Yes 3. I herewith confirm that the contact details saved in this system are those of the corresponding author, who will be notified about the status of the abstract. The corresponding author is responsible for informing the other authors about the status of the abstract.: Yes 4. 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