EACS2023: 943 Clinical characteristics and antiretroviral treatment patterns in HIV-2 infected patients: insights from a tertiary hospital in Portugal R. Rocha , C. Piñeiro , C. Caldas , A.S. Santos , R. Serrão , L. Santos Centro Hospitalar Universitário de São João, Infectious Diseases, Porto, Portugal General data Abstract category: Antiretroviral therapy – observational studies Abstract body Purpose: To describe the clinical characteristics of HIV-2 positive individuals on follow-up, with a focus on antiretroviral treatments. Method: Single-centre study conducted at a tertiary hospital in Portugal. All people living with HIV-2 on follow-up in this centre were included. Systematic and structured analysis of clinical records was applied to collect the data. Results: 56 patients were included, with median age of 65 years (IQR 58-73). 50.0% were female (28/56). Mode of HIV-2 acquisition: heterosexual transmission (72.2%), blood transfusion (25.9%), vertical (1.9%). 19.6% of individuals were diagnosed with coinfection with HBV, HCV, or both. Common comorbidities observed: dyslipidaemia (57.1%), hypertension (42.9%), diabetes mellitus (25.0%), osteoporosis/osteopenia (19.6%), malignancy (17.9%), and chronic kidney disease (8.9%). 19.6% had an AIDS-defining condition at diagnosis. Median CD4-cell count at diagnosis was 316/µL, 63.3% of patients with <200/µL. 36.0% of patients had detectable HIV-2 viral load at diagnosis (383-68100 copies/mL). 17.9% never initiated ART and maintained undetectable viral load and CD4-cell count >500/µL. Among those on ART (n=46), median time since start was 15.9 years (0.4-33.3) and, currently, 60.9% were on dual therapy (3TC/DTG). Other regimens included: 1 INSTI+2 NRTIs (26.1%), 1 INSTI+1 PI (6.5%). All patients except 4 were experienced in previous regimens. Among patients on 3TC/DTG the median follow-up time after switching to this regimen was 9.6 months; all patients had undetectable viral load before the switch and remained undetectable. Similar findings were seen for patients on 1 INSTI+2 NRTIs, with median follow-up time of 24.2 months. Conclusions: Managing HIV-2 infection poses challenges due to limited clinical experience, despite its generally milder progression. Dual therapy, although less extensively studied in HIV-2 infected patients, holds promise as a safe alternative for older individuals with multiple comorbidities. This highlights the importance of further research and exploration of treatment options tailored to the unique needs of people living with HIV-2. General conditions 1. I confirm that I previewed this abstract and that all information is correct. I accept that the content of this abstract cannot be modified or corrected after the submission deadline and I am aware that it will be published exactly as submitted.: Yes 2. I confirm that the submission of the abstract constitutes my consent to publication (e.g. conference website, programmes, other promotions, etc.). : Yes 3. I herewith confirm that the contact details saved in this system are those of the corresponding author, who will be notified about the status of the abstract. The corresponding author is responsible for informing the other authors about the status of the abstract.: Yes 4. I agree that all data provided may be used (saved, stored, processed, transmitted and deleted) in compliance with the privacy policy to provide the services described.: Yes 1 1 1 1 1 1 1 179
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