EACS2023: 925 Clinical characteristics and antiretroviral treatment efficacy among newly diagnosed migrants and refugees from Ukraine M. Parczewski , E. Siwak , I. Cielniak , M. Bociąga Jasik , M. Lara , M. Leszczyszyn-Pynka , M. Witak-Jędra , A. Szymczak , B. Szetela , E. Mularska , A. Witor , P. Jakubowski , M. Hlebowicz , B. Rozpłochowski , A. Olczak , W. Łojewski , E. Jabłonowska , K. Scheibe , P. Ząbek Pomeranian Medical University in Szczecin, Department of Infectious, Tropical Diseases and Acquired Immunodeficiency, Szczecin, Poland, Medical University in Warsaw, Department of Infectious and Tropical Disease and Hepatology, Warsaw, Poland, Collegium Medicum UKSW,, Faculty of Medicine, Warsaw, Poland, Jagiellonian University Medical College, Department of Infectious and Tropical Diseases, Kraków, Poland, Regional Hospital in Szczecin, Out-Patients' Clinics for Acquired Immunedeficency, Szczecin, Poland, Wroclaw Medical University, Department of Infectious Diseases, Liver Disease and Acquired Immune Deficiencies,, Wrocław, Poland, Regional Hospital Chorzów, Department of Infectious Diseases, Chorzów, Poland, Pomeranian Hospitals, Department of Infectious Diseases, Gdansk, Poland, University of Warmia Mazury in Olsztyn, Department of Family Medicine and Infectious Diseases, Olsztyn, Poland, Karol Marcinkowski University of Medical Sciences, Department of Infectious Diseases, Hepatology and Acquired Immunodeficiencies, Poznań, Poland, Faculty of Medicine, Nicolaus Copernicus University Ludwik Rydygier Collegium, Department of Infectious Diseases and Hepatology,, Bydgoszcz, Poland, Regional Hospital in Zielona Gora, Department of Infectious Diseases, Zielona Góra, Poland, Medical University of Lódz, Department of Infectious Diseases and Hepatology, Lódz, Poland, Hospital for Infectious Diseases, Molecular Diagnostics Laboratory, Warsaw, Poland General data Abstract category: Antiretroviral therapy – observational studies Abstract body Purpose: Late HIV diagnosis remains considerable problem, especially in migrant/refugee populations. Since the beginning of Russian invasion in Ukraine, Poland is not only mainlining care of already diagnosed people with HIV (PWH) but also diagnosing considerable number of new HIV infections among Ukrainian migrants and refugees. Here we present clinical and treatment outcome data in this group. Method: Clinical, laboratory, demographic and sequence data of 216 Ukrainian patients newly diagnosed with HIV-1 across Polish centres were analysed. For late diagnosis definition combination of AIDS and lymphocyte CD4 count<350 cells/μl was used. Antiretroviral treatment efficacy was analysed for the timepoint between 6 and 12 months from therapy initiation using viral load threshold of 200 copies/ml. Baseline sequences (118 for protease/reverse transcriptase and 44 for integrase) were used for analysis of transmitted drug resistance (Stanfrod HIV database) and subtyping (Comet tool). Results: Majority of cases were heterosexual (60.2%), female (55.5%) with median age of 37 (IQR:31-43) years, HIV-1 baseline viral load of 4.93 (IQR:4.17-5.58) log copies/ml and lymphocyte CD4 count of 189 (IQR:54-442) cells/µl (Table 1). A6 variant was the most prevalent with frequent non-nucleoside reverse transcriptase resistance (14.4%) mostly affecting rilpivirine. HIV was diagnosed at AIDS stage in 40% while 69.7% of patients were diagnosed late. Tuberculosis was the most common opportunistic infection (n=27, 39.7%, of these 25.9% with TB-drug resistance). The most common initial antiretroviral combinations were BIC/FTC/TAF (48.9%) followed by TDF/FTC+DTG (24.2%), 2NRTI+Raltegravir (7.3%) and 3TC/DTG (6.7%). Undetectable viral load was observed in 91.2% of patients following 6-12 months of treatment with median lymphocyte CD4 increase of 82 (IQR:21-163) cells/μl. Table 1. Clinical characteristics Ukrainian migrants with newly diagnosed HIV infection* Age, median (IQR) 37 (31-43) Gender , n (%) Male 96 (44.4) Female 120 (55.6) Transmission route, n (%) Heterosexual 130 (60.2) Men who have sex with men 18 (8.3) People who inject drugs 22 (10.2) Iatrogenic 1 (0.5) Undisclosed 45 (20.8) Lymphocyte CD4 count at care entry, cells/ul median (IQR) 189 (54-442) HIV-RNA levels at baseline, log copies/ml, median (IQR) 4.93 (4.17-5.58) Late diagnosis 147 (69.7) HBV surface antigen positive (HBsAg), n (%) 4 (2.54) Anti-HCV IgG antibody positive, n (%) 38 (24.1) HCV-RNA detectable (Only analysed in anti-HCV positive), n (%) 23 (74.2%) Syphilis non-treponemal serology - Venereal Research Disease Laboratory (VDRL) test, n (%) 14 (9.5%) HIV variant, n (%) - A6 108 (91.5) - B 9 (7.6) -D 1 (9.8) Drug resistance mutations n (%) -NRTI 4 (0.03) -NNRTI 10 (14.4) -PI 0 -Integrase 0 Follow-up data Lost to follow-up, n (%) & 30 (13.9) *Data availability: late diagnosis data for 211, HBs antigen for 157, anti-HCV antibody for 158 cases, HCV-RNA for 31, HIV1 subtype for 118 cases, VDRL for 146 cases Ten (8.5%) sequences with E138A polymorphism. & Three (1.5%) patients died Conclusions: In the group of Ukrainian migrants HIV infection was commonly diagnosed late, and often associated with tuberculosis. Transmitted resistance to rilpivirine was common, however antiretroviral treatment with integrase inhibitors warranted high rates of virologic success in this group. General conditions 1. I confirm that I previewed this abstract and that all information is correct. I accept that the content of this abstract cannot be modified or corrected after the submission deadline and I am aware that it will be published exactly as submitted.: Yes 2. I confirm that the submission of the abstract constitutes my consent to publication (e.g. conference website, programmes, other promotions, etc.). : Yes 3. I herewith confirm that the contact details saved in this system are those of the corresponding author, who will be notified about the status of the abstract. The corresponding author is responsible for informing the other authors about the status of the abstract.: Yes 4. 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