Table 3. Hazard ratios (HR) and Adjusted hazard ratios (AHR) of TF, TF excluding pregnancies, TFT and VF from fitting different Cox regression models in the different subgroups of interest for ART-experienced virologically suppressed PLWH switching to BIC/FTC/TAF HR 95%CI p AHR 95%CI p Age, >=50 years (vs <50 years) 0.85 0.63-1.1 0.27 0.88 0.64-1.2 0.428 Gender, female (vs. male) 1.44 1.01-2.1 0.042 1.43 1.00-2.04 0.052 HR 95%CI p AHR 95%CI p Age, >=50 years (vs <50 years) 0.91 0.67-1.24 0.559 0.94 0.69-1.30 0.748 Gender, female (vs. male) 1.16 0.78-1.70 0.461 1.13 0.77-1.68 0.523 HR 95%CI p AHR 95%CI p Age, >=50 years (vs <50 years) 1.34 0.69-1.59 0.389 1.18 0.58-2.38 0.645 Gender, female (vs. male) 0.94 0.39-2.27 0.896 0.88 0.36-2.14 0.781 HR 95%CI p AHR 95%CI p Age, >=50 years (vs <50 years) 0.67 0.29-1.6 0.369 1.00 0.41-2.5 1.000 Gender, female (vs. male) 3.48 1.53-7.9 0.003 2.78 1.19-6.5 0.019 HR 95%CI p AHR 95%CI p Age, >=50 years (vs <50 years) 0.73 0.29-11.87 0.522 0.94 0.35-2.50 0.909 Gender, female (vs. male) 2.64 1.04-6.7 0.041 2.38 0.91-6.23 0.077 Conclusions: Switching to BIC/FTC/TAF demonstrated high long-term effectiveness, including also in PLWH ≥50 years, consistent with data from RCTs. Higher risk of TF in females is mainly related to pregnancies concerns. General conditions 1. I confirm that I previewed this abstract and that all information is correct. I accept that the content of this abstract cannot be modified or corrected after the submission deadline and I am aware that it will be published exactly as submitted.: Yes 2. I confirm that the submission of the abstract constitutes my consent to publication (e.g. conference website, programmes, other promotions, etc.). : Yes 3. I herewith confirm that the contact details saved in this system are those of the corresponding author, who will be notified about the status of the abstract. The corresponding author is responsible for informing the other authors about the status of the abstract.: Yes 4. I agree that all data provided may be used (saved, stored, processed, transmitted and deleted) in compliance with the privacy policy to provide the services described.: Yes 1 2 1 2 1 2 1 2 1 2 165
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