EACS2023: 256 Pregnancy in women living with HIV in Latin America: a multi-centre cross-sectional analysis across seven countries P. Zitko , J. Ballivian , A.-P. Celi , C. Beltrán , A. Manzo , S. Sabato , E. Objeta , S. Lupo , N. Esquivel , O. Lopez , M. Lasso , R. Galvez , C. Chahin , E. Barthel , L. Montero , E. Delgado , W. Bosques , C. Mazariegos , R. Pinzon , S. Pereira , M. Morales , O. Sussmman , I. Cassetti Hospital Barros Luco Trudeau, Unite of Healthcare Research, Santiago, Chile, Hospital Braulio Moyano, Buenos Aires, Argentina, Hospital de Especialidades de las Fuerzas Armadas, Quito, Ecuador, Centro de Especialidades Médicas Ambulatorias, Mar del Plata, Argentina, Fundación del Centro de Estudios, Buenos Aires, Argentina, Hospital de Boulogne, Buenos Aires, Argentina, Centro de Asistencia e Investigación Clínica Integral, Rosario, Argentina, Hospital Ernesto Torres Galdámez, Iquique, Chile, Hospital Dr Sotero Del Rio, Santiago, Chile, Hospital Dr. Juan Noé, Arica, Chile, Hospital Doctor Hernán Henríquez Aravena, Temuco, Chile, Hospital Carlos Van Buren, Valparaiso, Chile, TODOMED, Cali, Colombia, Vivir Bien IPS, Cartagena, Colombia, Hospital Monseñor Sanabria, El Roble, Costa Rica, Hospital Regional De Zacapa, Zacapa, Guatemala, Hospital Roosevelt, Guatemala, Guatemala, Asociación Española, Montevideo, Uruguay, Ambulatorio La GuairaVargas, La Guaira, Venezuela, Infectoclinicos, Bogota, Colombia, Helios Salud Ambulatory AIDS Care Centre, Buenos Aires, Argentina General data Abstract category: Access and delivery of care Abstract body Purpose: To describe relevant features of pregnant care of Women Living With HIV (WLWH) in the Latin American Workshop Study Group on HIV (LAWSG) initiative. Method: We performed a cross-sectional analysis using aggregated administrative data from the LAWSG centres. Outcomes were defined as pregnancies that ended in 2019. Random-effects meta-analyses were conducted to account for variability between centres (I centres) and countries (I countries). Results: A total of 17 of the 101 centres from seven Latin American countries completed the data collection, gathering information from 194 pregnancies. The pregnancy rate in women undergoing HIV treatment was 1.7% (95% confidence interval [CI]=0.7–2.6%). In 42.0% (95%CI=24.6–59.5%; I for centre=9.5%; I for country=52.7%) of the cases, HIV was diagnosed after pregnancy confirmation. A total of 30.0% (95%CI=18.8–41.2%; I centre=29.2%, I country=0.0%) of the WLWH had a first CD4+ count of <350 cells/mL. Antiretroviral therapy (ART) was discontinued in 8.2% (95%CI=2.4–14.0%; I centre and I country=0.0%) of the cases. By the last trimester of pregnancy, 76.4% (95%CI=53.6–99.3%; I centre=43.2%, I country=40.2%) of the WLWH had an undetectable viral load. The ART regimes mainly included TDF/xTC as a backbone plus various options for a third drug. Most pregnancies ended by term caesarean section (87.8%; 95%CI=65.8–109.8%; I centre=36.9%, I country=48.4%), maintaining control until the third month after delivery. Among those who visited the centre three months after delivery, 95.3% (95%CI=90.8–99.9%; I2centre=17.1%, I2country=0.0%) avoided breastfeeding. Conclusions: Increasing HIV detection among women of reproductive age and ensuring continuity of care for WLWH to avoid pregnancies outside of ART are necessary. Continuity of care should be safeguarded, including during postpartum visits. Healthcare services should be particularly sensitive to women’s needs during pregnancy. General conditions 1. I confirm that I previewed this abstract and that all information is correct. I accept that the content of this abstract cannot be modified or corrected after the submission deadline and I am aware that it will be published exactly as submitted.: Yes 2. I confirm that the submission of the abstract constitutes my consent to publication (e.g. conference website, programmes, other promotions, etc.). : Yes 3. I herewith confirm that the contact details saved in this system are those of the corresponding author, who will be notified about the status of the abstract. The corresponding author is responsible for informing the other authors about the status of the abstract.: Yes 4. I agree that all data provided may be used (saved, stored, processed, transmitted and deleted) in compliance with the privacy policy to provide the services described.: Yes 1 2 3 1 4 5 6 7 8 8 9 10 11 12 13 14 15 16 17 18 19 20 21 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 2 2 2 2 2 2 2 2 2 2 2 2 14 19TH EUROPEAN AIDS CONFERENCE | WARSAW 2023
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