PI-based 2-drug regimen DTG/3TC DTG/RPV PI-based Non-standard regimen PI monotherapy 36 (13.04) 49 (14.98) 42 (85.71) 5 (10.2) 2 (4.08) 2 (0.61) 2 (100) Proportion with co-morbidities Number of co-morbidities 1 2 3 4 5 >5 150 (45.87) 65 (43.33) 34(22.67) 28 (18.67) 11 (7.33) 3 (2.00) 9 (6.00) Proportion on Concomitant Medications Number of drugs 1 2 3 4 5 >5 95 (28.13%) 32 (34.78) 12 (13.04) 19 (20.65) 3 (3.26) 5 (5.43) 21 (22.83) TDF: Tenofovir disoproxil; TAF: Tenofovir alafenamide; ABC: Abacavir; INSTI: Integrase inhibitor; NNRTI: Non-nucleoside reverse transcriptase inhibitor; RPV: Rilpivirine; DTG: Dolutegravir; PI: Protease inhibitor; 3TC: Lamivudine Table 2: Clinic Processes Site Number of participants Clinic 1 (9) Clinic 2 (92) Clinic 3 (21) Clinic 4 (19) Clinic 5 (26) Clinic 6 (45) Clinic 7 (12) Clinic 8 (20) Clinic 9 (85) Screening Tool Criteria EMEA Licensing Criteria HIV-1 RNA<50 NNRTI/INSTI resistance VF on NNRTI/INSTI Hep B sAg X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X X Additional BHIVA Criteria: Likelihood to attend BMI <30kg/m2 Non-A1/6 subtype X X X X X X X X X X X X X X X X X X X Other Criteria: Hep B immunity Pregnancy +/- risk Psychological issues X X X X X X X X Multidisciplinary Team (MDT) MDT approval required? Frequency of MDT meeting Yes 1x/week Yes 2x/month Yes 2x/week Yes 2x/month Yes 1x/month Yes 1x/week Yes 1x/week Yes 3x/month Yes 1x/month SOP in place? Yes Yes Yes Yes Yes In draft In draft Yes Yes Reminder system for appointments? Method of reminder Yes 2 x SMS Yes 2 x SMS Yes Call + 2 x SMS Yes E-mail or SMS No n/a Yes Mobile app Yes SMS Yes SMS Yes Call + SMS Abnormal results system Nurse worklist and clinic recall system Nurse B6/7 + Consultant MDT review Consultant Pharmacist Clinic recall system Nurse B7/8 recall Nurse B7 recall Nurse B6/7 recall Staff delivering LAI Nurse B6/7 Nurse B5/6/7/8 Nurse B7 Nurse B6/7 Nurse B6 Nurse B6/7 Nurse B6/7/8 Nurse B7/8a Nurse B6/7/8 Appointment Length No. of patients/session 30 2-4 30 2-4 30 3-6 40 4 30 n/a (OPAT) 30 4-13 45 4 45-60 4 40 5-9 Time from MDT approval to starting LAI (Median days, IQR) 42 (12-83) 35.5 (14-167) 22 (18-28) 58 (20-78) 47.5 (19-82) 29 (8-88) 22 (8-93) 49 (35-55) 77 (31-134) A multi-disciplinary team (MDT) is a group of healthcare staff with different professions (e.g. doctors, nurses, pharmacists), that work together to make decisions regarding the treatment of individual patients. A Standard Operating Procedure (SOP) is a set of written instructions describing the step-by-step process by which the long-acting injectable medications are stored, delivered and administered as well as providing detail on patient monitoring and management of missed doses. Nurses are placed in pay-scale bands based on experience and seniority. Band 5: newly qualified or staff nurse. Band 6: senior nurse or nursing specialist. Band 7: advanced nurse or nurse practitioner. Band 8: modern matron, chief or head nurse. Conclusions: Our service evaluation shows that female inclusion was lower than the country prevalence, highlighting potentially lower awareness and/or uptake in women which warrants further study. There were few discontinuations and 98% received on-time injections. 6% of people were prescribed LA-I outside of the EMEA license criteria despite rigorous screening processes. Gaps between approval and 1 injections were lengthy; appointment durations were longer than specified in national cost-effectiveness models. General conditions 1. I confirm that I previewed this abstract and that all information is correct. I accept that the content of this abstract cannot be modified or corrected after the submission deadline and I am aware that it will be published exactly as submitted.: Yes 2. I confirm that the submission of the abstract constitutes my consent to publication (e.g. conference website, programmes, other promotions, etc.). : Yes 3. I herewith confirm that the contact details saved in this system are those of the corresponding author, who will be notified about the status of the abstract. The corresponding author is responsible for informing the other authors about the status of the abstract.: Yes 4. I agree that all data provided may be used (saved, stored, processed, transmitted and deleted) in compliance with the privacy policy to provide the services described.: Yes a b c a b c st 111
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