International Society for Pediatric and Adolescent Diabetes
ISPAD 2014 | 40th Anniversary |
259
P170
Comparison of
β
-cell function and complications among babies born to mothers with or
without gestational diabetes mellitus - one year cross sectional study
S.M. Jali
1,2
, I. Kori
1
1
KLE University's J.N. Medical College, Department of Pediatrics, Belgaum, India,
2
KLES Dr.
Prabhakar Kore Hospital & Medical Research Centre, Pediatric Diabetes Consultant, Diabetes Centre,
Belgaum, India
Objectives:
Gestational Diabetes Mellitus carries significant burden on individuals and healthcare
services through its complications affecting both mother and baby. This study was aimed to assess
outcomes in babies born to GDM mothers like raised C-peptide levels, hypoglycemia,
hyperbilirubinemia and macrosomia.
Methods:
One year cross sectional study was conducted in the Department of Pediatrics. Babies born
to mothers with and without GDM (n=30+30) were included for the study.Mothers with predisposing
illnesses and not willing to consent were excluded. HbA
1C
and blood glucose levels were noted in
GDM mothers. Estimation of Serum C-peptide levels, random blood glucose at birth, 1,4 and 6 hr of
life and serum bilirubin done in moderately icteric babies of GDM mothers using Kramer's scale,
wherein RBS was done at birth in babies of normal mothers. Birth weights were recorded.
Results:
The mean HbA1c levels in GDM mothers were 13.8 ± 2.34. In the present study, 28.9%
mothers delivered late preterm babies compared to 4.4% in control group. Further, 60% babies were
born by caesarean section in test group versus 6% in control (P=0.002); 30% had birth weight more
than 3500 grams versus 3.3% control (P=0.027) respectively. In the study group, hypoglycemia (the
mean blood glucose levels 41.5mg/dL) was noted in 83.3% versus 0% in Control (p< 0.001). All
babies in the test group and control group had normal C- peptide levels. However, 66.6% of babies in
the test group had C- peptide levels on higher normal as compared to 24.9% in control group
(p=0.001). In the present study, in the test group 66.33% had hyperbilirubinemia verses 30% in
Control (P=0.010).
Conclusion:
Babies born to uncontrolled GDM mother are prone to have higher C-peptide level which
may predict early onset of diabetes in these children. The complications such as hypoglycaemia,
hyperbilirubinemia and macrosomia are higher in these babies and hence these children must be
monitored closely after birth.
