Conference Resources | Abstracts
September 3
rd
– 6
th
, 2014 | Toronto, Canada |
252
Poster Tour 21: Acute and Chronic Complications VI
P164
Combined use of urinary neutrophil gelatinase associated lipocaline (uNGAL) and renal
resistance index as early predictors of diabetic nephropathy in children and adolescents with
type 1 diabetes mellitus
S.M. Farid Ahmed
1
, A.A. Hamed
1
, A.A. Abas
2
, W.A.A. Mohamed
1
1
Ain Shams University, Pediatrics, Cairo, Egypt,
2
Ain Shams University, Clinical Pathology, Cairo,
Egypt
Background:
Although diabetes related renal disease is rare in childhood, yet early subclinical
abnormalities may be present many years before overt manifestations.
Objective:
We aimed to evaluate the level of urinary neutrophil gelatinase-associated lipocalin
(uNGAL) and the intrarenal resistive index (RI) as an early detector of diabetic nephropathy in children
with type 1 DM.
Plan:
Seventy patients with T1DM were recruited from diabetes clinic, Ain-Shams University Hospital,
they were divided into 2 groups; Group 1: with normoalbuminuria (< 30 mg/24 hrs) and Group 2: with
microalbuminuria (30-300 mg/24 hrs). Controls consisted of 40 healthy children and adolescents
matched in age, gender to the diabetic groups. Urinary NGAL was measured using ELISA and the
doppler sonography of the interlobar arteries was performed for all participants.
Results:
Patients with T1DM had a higher uNGAL level compared to controls (p< 0.01), with higher
value in group 2 compared to group 1. The mean resistive index of the right and left kidneys was
higher in diabetic groups compared to controls. UNGAL was positively correlated with both serum
creatinine and urinary microalbumin excretion.
Conclusions:
Our data suggest that; evaluation of uNGAL excretion and Doppler intrarenal RI could
be a useful complementary test in the evaluation of early stages of diabetic nephropathy. Longitudinal
monitoring may better define their relevance in progressive kidney disease.
