International Society for Pediatric and Adolescent Diabetes
ISPAD 2014 | 40th Anniversary |
239
P151
Polycystic ovary syndrome and hyperandrogenism in type 1 diabetes: adolescent girls are
already at risk
L.E.P. Calliari
1
, L. Barros
1
, R.M. Noronha
1
, A.C.R. Ribeiro
2
, O. Monte
3
1
Santa Casa Faculty of Medical Sciences, Pediatric Endocrine Unit, Pediatric Department, Sao Paulo,
Brazil,
2
Santa Casa Faculty of Medical Sciences, Ultrasound Unit, Diagnostic Imaging Department,
Sao Paulo, Brazil,
3
Santa Casa Faculty of Medical Sciences, Endocrine Unit, Internal Medicine
Department, Sao Paulo, Brazil
Background:
Although it has been described that adult women with Type 1 Diabetes (T1D) have a
high prevalence of Polycystic Ovary Syndrome (PCOS), and that it can initiate during puberty, there
are no reports in the literature about the prevalence of PCOS exclusively in adolescents with T1D .
Objective
: The present study has the objective of determining the prevalence of PCOS in adolescents
with T1D, and evaluating the diagnostic criteria in this age group.
Methods:
We evaluated 22 T1D patients, with chronological age (CA) between 12 and 20 years.
Antecedents of menarche and menstrual cycles were obtained through a structured questionnaire,
and the clinical signs of hyperandrogenism through physical examination. We performed, in all cohort,
biochemical exams (androstenedione, testosterone and DHEA sulfate) and ovarian ultrasonography.
PCOS diagnosis was defined by Rotterdam criteria.
Results:
From the 22 patients (CA = 16,7 ± 2,2 years), 5 (22,7%) fulfilled criteria to PCOS and 17
(77,3%) were classified as NON-PCOS. Hirsutism was found in 60% (3/5) of those PCOS and in 5,8%
(1/17) of the NON-PCOS. Lab hyperandrogenism was found in 6/22 patients, 2/5 from the PCOS-
Group. Ultrasonographic alterations compatible with PCO Morphology (PCOM) were found in 100% of
the PCOS patients, and in none from the NON-PCOS
Conclusions:
To our knowledge, this is the first study that evaluates the association, exclusively in
adolescents, between T1D and PCOS.
We found a high prevalence of PCOS, similar to what is described in adult patients with T1D. Our
results suggests, besides, that clinical data (hirsutism or oligomenorrhea), associated to typical
features of ovarian US (performed by experienced professional and with strict criteria), independently
of biochemical results, could detect precociously all cases of PCOS. Diagnosis of PCOS in this early
phase could lead to specific treatments and avoid the progression of the disease and late
consequences in adult life.
