Conference Resources | Abstracts
September 3
rd
– 6
th
, 2014 | Toronto, Canada |
238
P150
Cardiometabolic risk in healthy Chilean adolescents: influence of physical inactivity and
sarcopenia
R. Burrows
1
, P. Correa
1
, M. Reyes
1
, E. Blanco
2
, S. Gahagan
2
, C. Albala
1
1
University of Chile, Institute of Nutrition and Food Technology, Santiago de Chile, Chile,
2
University of
California San Diego, Division of Child Development and Community Health, San Diego, United States
Objective:
We examined whether physical inactivity and sarcopenia in adolescents were associated
with higher cardiovascular risk as measured by the Metabolic Syndrome (MetS).
Methods:
In 667 adolescents (16.8±0.2 years old) from a longitudinal follow-up, physical activity was
measured by the total amount of time devoted to sedentary activities, recreational games, active
commuting, and weekly scheduled exercise. Fat and muscle mass were assessed with DEXA. Fat-
Free Mass Index (FFMI) was estimated. Percentage values of FFMI ≤ 25th percentile in our sample
were considered sarcopenia, after adjusting for sex. BMI, waist circumference (WC), blood pressure
(BAP), triglycerides (TG), HDL-cholesterol, glucose, insulin and HOMA-IR were measured. MetS was
diagnosed according to the IDF. Logistic models assessed the relation between physical inactivity and
sarcopenia, and the odds of MetS, after adjusting for confounders or mediating factors, including sex,
obesity
(B
MI z≥ 2 SD) and insulin resistance (HOMA
-
IR ≥3.3).
Results:
Seventy-nine percent of adolescents had at least one cardiovascular risk factor (CVRF) and
9.2% had MetS. Forty percent of participants were physically inactive and 37% had sarcopenia.
Having three or more CVRF (MetS) significantly increased BMI z-score, WC, fat mass, BAP, TG,
glycemia, insulin and HOMA-IR, and lowered HDL-chol and lean mass. Physical inactivity (OR: 2.7 CI:
1.3-5.6) and sarcopenia (OR: 6.9 CI: 2.7-17.6) significantly increased the risk of MetS.
Conclusions:
In adolescents, we found a high prevalence of obesity, abdominal obesity, dyslipidemia,
fasting hyperglycemia and MetS. Physical inactivity and low muscle mass were both predictor of MetS.
Sarcopenia was a stronger risk indicator of MetS than obesity and insulin resistance.
Funding:
NHLBI/NIH (grant nº R01HL088530).
