International Society for Pediatric and Adolescent Diabetes
ISPAD 2014 | 40th Anniversary |
237
Poster Tour 19: Diabetes and Adolescence
P149
Insulin resistance is independently associated with a reduced muscle mass in healthy Chilean
adolescents
R. Burrows
1
, P. Correa
1
, M. Reyes
1
, E. Blanco
2
, C. Albala
1
, S. Gahagan
2
1
University of Chile, Institute of Nutrition and Food Technology, Santiago de Chile, Chile,
2
University of
California San Diego, Division of Child Development and Community Health, San Diego, United States
Objective:
We examined whether low muscle mass in 668 Chilean adolescents (16.8±0.3 years old)
from a longitudinal follow-up was associated with higher risk of insulin resistance (IR).
Methods:
BMI, waist circumference (WC), glucose, insulin, adiponectin, diet and physical activity (PA)
habits were measured. Fat and fat free mass (%) were assessed with DXA. Fat Mass Index (FMI) and
Fat-
Free Mass Index (FFMI) were estimated. Percentage values of FFMI ≤ 25
th
percentile in our
sample were considered low muscle mass, after adjusting for sex. Data on family history of DM2 in 1st
degree relatives (FHDM) was self-reported. HOMA-
IR was calculated and values ≥2.6 were
considered insulin resistance (IR). We used bivariate and multivariate regression analysis to examine
the association between low muscle mass and IR. Multiple logistic regressions assessed the
relationship between low muscle mass (exposure) and the odds of IR (outcome). Models were
adjusted for potential confounders: obesity (BMI z-
score ≥2 sd), abdominal obesity
(IDF), physical
inactivity, low adiponectine and FHDM.
Results:
16.3% of adolescents had IR. Adolescents with IR showed significantly higher mean values
of BMI z-score, WC, fat mass (%), glucose and insulin, and significantly lower mean values of lean
mass (%) and adiponectin. We found a significant association between IR and obesity (crude OR: 6.6;
95% CI: 4.1-10.6), abdominal obesity (crude OR: 3.8; 95% CI: 2.5-5.7), low muscle mass (crude
OR:4.9; 95% CI:3.2-7.5), low adiponectin (crude OR:2.5; 95% CI:1.6- 4.0 ), low PA (crude OR:1.8:
95% CI: 1.2-2.7 ) and FHDM (crude OR:1.7; 95% CI:1.1-2.9). Low muscle mass was significantly
associated with IR, after adjustment for obesity, abdominal obesity, low PA, low adiponectin, and
FHDM.
Conclusions:
Healthy adolescents with reduced muscle mass showed a higher risk of IR,
independent of obesity status, adiponectin levels and FHDM.
Funding:
NHLBI/NIH (grant nº R01HL088530).
