Conference Resources | Abstracts
September 3
rd
– 6
th
, 2014 | Toronto, Canada |
230
P140
Frequency of diabetes complications in children with DM1 in Ukraine, which were treated by
CSII vs MDII
E. Globa
1
, N. Zelinska
1
1
Ukrainian Center of Endocrine Surgery, Endocrine Organs and Tissue Transplantation, MoH of
Ukraine, Kiev, Ukraine
Objectives:
The frequency of acute and chronic diabetes complications as well as HbA1c level were
compared in two groups of children with DM1, which were treated by continuous subcutaneous insulin
infusion (CSII) and multiple daily insulin injections (MDII).
Methods:
We created Ukraine Pediatric Diabetes Register in 2004. It contains all information about
children with DM1 aged 0-18 y.o., including the frequency of acute complications (diabetes
ketoacidosis (DKA) and severe hypoglycemias (SH), chronic complications (cataract, retinopathy,
nephropathy, peripheral neuropathy (PN), steatohepatosis, hairopathy, microangiopathy of lower
extremities), children without chronic complication, HbA1c level, etc.
Results:
We studied a database of 401 children aged 10,5±4,5 y.o., with duration of DM 4,4±3,4 y.,
which were treated by CSII vs 7426 children which were treated by MDII, aged 12,1±4,4 y.o., with
duration of DM 4,3±3,7 y. (p>0,05).
The most of the children who used the CSII were aged 6-10 y.o. (30,7%) and had a duration of DM1 1-
5 years (61,4%).
Diabeti
c
catarac
t
Diabetic
retinopath
y
Diabetic
nephropath
y
Diabeti
c PN
Diabetic
microangiopath
y
No chronic
complicatio
n
DK
A 2-
3
S
H
HbA1c,
%
CSII
(n=401) 0,3*
1,5*
7,3
19,5
8,8*
61,4
7,9* 1,
1
8,0±1,7
*
MDII
(n=7426
)
1,6
4,9
9,9
17,9
14,2
58,1
11,4 0,
5 8,8±1,9
[The frequency of acute and chronic complications]
* - p< 0,05
The frequency of diabetic steatohepatosis and hairopathy in CSII group was 16,0 and 14,1% vs 12,8
and 6,4% in MDII group accordingly.
Conclusions:
Children who were treated by CSII had lower rate of diabetic cataract, retinopathy,
microangiopathy of lower extremities and DKA 2-3 as well as lower HbA1c level vs children who were
treated by MDII (p< 0,05).
