ECFS 2020 - Optimizing pharmaceutical care in cystic fibrosis

European Cystic Fibrosis Society   177  OPTIMIZING PHARMACEUTICAL CARE IN CYSTIC FIBROSIS EVALUATION AND MANAGEMENT OF BETA-LACTAM ANTIBIOTIC DRUG REACTIONS CHAPTER 10 Figure 3: Example of a 12-step protocol for rapid intravenous desensitization to ceftazidime. Reproduced from [32] Name of medication: Ceftazidime Total mg per bag Amount of bag infused (mL) Solution 1 100 mL of 0.200 mg/mL 20.00 9.25 Solution 2 100 mL of 2.000 mg/mL 200.00 18.75 Solution 3 100 mL of 19.607 mg/mL 1960.65 250.00 Step Solution Rate (mL/h) Time (min) Volume infused per step (mL) Dose admin- istrated with this step (mg) Cumula- tive dose (mg) 1 1 2.0 15 0.50 0.100 0.100 2 1 5.0 15 1.25 0.250 0.350 3 1 10.0 15 2.50 0.500 0.850 4 1 20.0 15 5.00 1.000 1.850 5 2 5.0 15 1.25 2.500 4.350 6 2 10.0 15 2.50 5.000 9.350 7 2 20.0 15 5.00 10.000 19.350 8 2 40.0 15 10.00 20.000 39.350 9 3 10.0 15 2.50 49.016 88.366 10 3 20.0 15 5.00 98.0325 186.399 11 3 40.0 15 10.00 196.065 382.464 12 3 80.0 61.87 82.50 1617.536 2000.00 Total time = 226.875 minutes (3h 46m)